Molecular chaperones and components of the proteasome can also be found in aggregates formed in transgenic animal models and transfected cell cultures by various polypeptides with expanded polyQ [61–66], mutant SOD1, (familial ALS) [67], α-synuclein (α-Syn), (PD) [68], intracellular tau tangles, and extracellular plaques formed in AD [69]. Here, MAPT is linked to Alzheimer disease.