Fusions between ETV6 and phospho-tyrosinkinases (PTKs) are found in a variety of hematological diseases where the HLH domain is essential for the aberrant function of the fusion product, e.g. chronic myelomonocytic leukemia (CMML), AML, acute lymphoid leukemia (ALL) or myelodysplastic syndrome (MDS) [1]. This evidence concerns the gene ETV6 and acute lymphoblastic leukemia.