Fusions between ETV6 and phospho-tyrosinkinases (PTKs) are found in a variety of hematological diseases where the HLH domain is essential for the aberrant function of the fusion product, e.g. chronic myelomonocytic leukemia (CMML), AML, acute lymphoid leukemia (ALL) or myelodysplastic syndrome (MDS) [1]. The gene discussed is ETV6; the disease is myelodysplastic syndrome.