MAPT and Leber hereditary optic neuropathy: The distribution of MAPT H1/H2 haplotypes and genotypes in both affected LHON cases and unaffected LHON mtDNA mutation carriers was not significantly different to published population controls (Skipper et al., 2004) (affected LHON cases versus published controls P = 0.613 and unaffected LHON mtDNA mutation carriers versus published controls P = 0.727, Table 1).