Our study is the first study to report any treatment effects of 106, 109 or 136 on the FXN upstream GAA region acetylation status of residues H3K9 and H4K12; the two histone residues that show the greatest deacetylation in FRDA disease (Al-Mahdawi et al., 2008; Herman et al., 2006; Soragni et al., 2008). Here, FXN is linked to Friedreich ataxia.