Daily supplements with 80 mg zinc, 2 mg copper, vitamins C and E, and β carotene are recommended by AREDS as a means of reducing the risk for progression to advanced AMD.43,44 Interestingly, the AREDS-recommended zinc supplements with antioxidants were recently correlated with a greater reduction in progression to advanced AMD in patients who are homozygous for the FH Tyr402 allotype (wild type; 34% of cases) compared to patients who are homozygous for the FH His402 allotype (AMD risk; 11% of cases).45 This evidence concerns the gene FH and age-related macular degeneration.