When two neuroblastoma cell lines were separated in CD133+ and CD133–fractions by magnetic microbeads and tested for chemosensitivity, the phosphorylated forms of both ERK and p38 kinases, which indicates activation and has been associated with cell survival mechanisms, were expressed at higher levels in CD133+ cells, and those cells were more resistant to commonly used treatment drugs including cisplatin, carboplatin, doxorubicin and etoposide [100]. The gene discussed is PROM1; the disease is neuroblastoma.