Progression to adenocarcinoma was accelerated in the MPAKT/Hi-MYC model with evidence of invasion in 8% of mice at 5–9 weeks, and in 67% mice at 16–20 weeks, compared respectively with 0% and 25% of Hi-MYC mice (Figs. 3A, 3D, 4; sample size precluded statistical significance). This evidence concerns the gene MYC and adenocarcinoma.