In the Hi-MYC model [28], the modified (ARR2PB) probasin promoter-driven expression of human MYC in the prostate results in murine prostate intraepithelial neoplasia (mPIN) in the lateral prostate (LP) by 4 weeks of age that progresses to adenocarcinoma in all mice by 6–9 months. Here, MYC is linked to adenocarcinoma.