SHH and gastric cancer: SHH pathway plays a critical role in many CSCs, such as glioblastoma stem cells [1], [2], CD34+ leukemic cells[3], [4] and breast CSCs[5], in addition, it is crucial to the development and homeostasis of gastric gland[6], abnormal activation of the SHH pathway could result in gastric cancer[7], [8], however, the role of SHH pathway in gastric CSCs is not clear.