MYC and neoplasm: Also c-myc and the viral oncogene E1A were described to cause the up-regulation of p73 levels and to trigger p73-dependent apoptosis in vitro, suggesting that, similarly to p53, p73 might be involved in a tumor suppressor circuitry that responds to restrict aberrant oncogenic signals in vivo, as recently demonstrated in the case of c-Myc-driven lymphomagenesis [79-81].