In CLL cells, lenalidomide stimulates transcription of CD154 (the CD40-ligand) via the NFATc1 (Nuclear Factor of Activated T cells c1)/NF-kB complex, and promotes stabilization of CD154 mRNA via the phosphoinositide-3 (PI3)-kinase pathway [147]. This evidence concerns the gene CD40LG and B-cell chronic lymphocytic leukemia.