The differences between p73-/- and TA-p73-/- mice not only proved the involvement of TA-p73 in tumor suppression, but indirectly pointed out the oncogenic potential carried by ∆N-p73 isoforms, thus highlighting the importance of a proper balance between TA- and ∆N-isoforms to maintain genomic fidelity in proliferating cells (see below). This evidence concerns the gene TP73 and neoplasm.