DTNBP1 and hydrops fetalis: The present study demonstrates (1) that the three major dysbindin-1 isoforms are synaptically located in the human brain, (2) that they are differentially distributed in synaptic compartments, (3) that one or more of these pre- and/or post-synaptically localized isoforms are significantly reduced in synaptosomes of the pSTG and HF in schizophrenia without loss of synaptic vesicle or PSD markers.