Recently, the protective effect of Sirt3 under oxidative stress was shown in cardiomyocytes [40], where it was shown that Sirt3 reduced ROS generation in cardiomyocyte under cardiac hypertrophy by enhancing antioxidant enzymes such as manganese superoxide dismutase (MnSOD) and catalase. The gene discussed is SIRT3; the disease is cardiac hypertrophy.