Therefore, our study and theirs independently demonstrate the phosphorylation-dependent binding of 14-3-3 to LRRK2, which may play a critical role in regulating LRRK2 function in vivo; PD-linked mutations impair 14-3-3 interaction with LRRK2 and thus disturb the regulation of LRRK2 by 14-3-3. This evidence concerns the gene YWHAQ and Parkinson disease.