TGFB1 and neoplasm: Tumor depth (P = 0.017), histological entity (P = 0.027), malignancy grade (P<0.001), metastasis at time of diagnosis (P = 0.011), surgery (P = 0.002), non-free resection margins (P<0.001), and TGF-β1 expression (P = 0.035) were significant independent prognostic indicators of DSS.