Down-regulation of tropomyosin 2 via epigenetic silencing in human ovarian cancer has been reported [54] and recent results in our laboratories using 5′aza deoxycytidine treatment suggest that tropomyosin 2 as well as α-actinin and vinculin are epigenetically silenced in MOSE-L cells (unpublished observations). This evidence concerns the gene VCL and ovarian carcinoma.