To further explore the hypothesis that the actin/tubulin cytoskeleton changes during the progression of MOSE-E to MOSE-L cells could lead to an incorrect localization/scaffolding of proteins and change signal transduction pathways, we analyzed integral signaling proteins that have also been implied in ovarian cancer development: protein kinase C β II (PKCβII) and adenomatous polyposis coli (APC). This evidence concerns the gene APC and ovarian cancer.