MAPT and behavioral variant of frontotemporal dementia: The inclusion pathologies underlying the clinical presentation of bvFTD are variable and remain difficult to predict in life, as clinical cases are evenly distributed between tau- and TDP-positive inclusions.24,25 Our postmortem analyses, however, demonstrated that hypothalamic atrophy was much more severe in cases with TDP-positive inclusions compared to cases with tau-positive inclusions.