HCRT and attention deficit-hyperactivity disorder: Similar disruption of the dorsomedial hypothalamic nucleus in association with hyperactivity of the orexin neurons in LH has been proposed to underlie the binge feeding in attention-deficit/hyperactivity disorder.29 The combination of pathology-specific neuronal loss together with the preservation of neurons containing peptides involved in feeding regulation may have considerable clinical implications as targeted therapeutic interventions are developed.