Activation of these pathways orchestrates a series of responses mediated by downstream centers including the paraventricular nucleus (PVN) to control thyroid hormone secretion, feeding behavior, and energy conservation, and by lateral hypothalamic (LH) orexin-producing neurons to control arousal responses and feeding behavior (see Fig 1).12 The hypothalamus in FTD has received only limited attention13; its contribution to eating disturbance in FTD has not been studied to date, and may have relevance for disease management. This evidence concerns the gene TG and frontotemporal dementia.