For example, variants in STUB1 and ADRβ2 genes in Caucasian and variants in CHIA and ADIPOQ genes in African American were not associated with asthma in the single SNP analysis; however, in conditional inference framework taking rs2243250 and rs4848492 as a major discriminatory SNPs in Caucasian and African American respectively, variation in these genes is highly associated with asthma (p<0.01). The gene discussed is ADIPOQ; the disease is asthma.