Secondly, Using RP, we report for the first time an interaction of six genes affecting European ancestry pediatric asthma: rs2243250 (IL4), rs6597 (STUB1) rs11168070 (ADRβ2), rs3024676 (IL4Rα), rs638376 (IL13Rα2) and rs3806446 (CHIA). This evidence concerns the gene IL4 and asthma.