The IFN-DC-mediated induction of CD4 T cells co-expressing IFN-γ and IL-17, the Th1/Th17 cells, is also interesting in the light of the evidence that in patients with certain autoimmune diseases (e.g. Crohn disease, uveitis), a considerable fraction of T cells secreting IL-17 in the tissue was described to express both IFN-γ and IL-17 [28], [29]. Here, IFNA1 is linked to autoimmune disease.