An expansion of CCR6/CCR4 double positive cells was found to occur also upon stimulation of naive CD4 T cells with IFN-DC fed with apoptotic autologous PBLs (Fig. 7D), arguing against the possibility that the Th17-inducing capability of apoptotic cell-loaded IFN-DC was dependent on tumor cell-specific factors. Here, CCR4 is linked to neoplasm.