Since Th17 lymphocytes have been implicated in the pathogenesis of autoimmune disorders, these findings are instrumental in understanding how IFN-α, by shaping DC functions including IL-23 release, can induce autoimmunity, thus leading to a more comprehensive vision of the role of this cytokine in the regulation of the immune response under both physiological and pathological conditions. Here, IL23A is linked to Autoimmunity.