Downregulation of DRAM in human cancer, like in melanomas [56], not only permits the survival of stress damaged cells, but also contributes to the maintenance of proteins which promote progression of the cell cycle, as is the case of VRK1, implicated in early G0/G1 [13] resulting in a mitotic delay [57], and required for Golgi fragmentation in mitosis [39], but which is likely to have additional roles along the cell cycle. The gene discussed is VRK1; the disease is melanoma.