By MSP, 8 out of 12 genes (CDH1, CDH13, DBC1, SFRP1, SYK, TAL1, TP73 and WNT5A) were methylated in both ALL derived cell lines, 3 were unmethylated (CDKN1A, FHIT and RASSF1A) and 1 was methylated in TOM-1 cell line and unmethylated in NALM-20 cell line (MGMT) (Figure S2 and S3) [10], [19], [20], [21], [22]. This evidence concerns the gene FHIT and acute lymphoblastic leukemia.