Due to the fact that deregulation of the TP53 pathway is a hallmark of cancer while function of p53 is abnormal in ALL despite the rare occurrence of TP53 mutations in ALL [7], the abnormal hypermethylation of these genes prompted us to perform a new unsupervised analysis with all the genes implicated in the TP53 pathway included in the Illumina array. Here, TP53 is linked to acute lymphoblastic leukemia.