Significant differences for Skp2 staining were observed between normal and dysplastic nevi (P = 0.039, χ2 test), dysplastic nevi and primary melanoma (P = 0.008, χ2 test), and primary and metastatic melanoma (P = 0.008, χ2 test) (Figure 2E). Here, SKP2 is linked to dysplastic nevus.