Next, we separated all melanoma (n = 392) into primary melanoma (n = 259) and metastatic melanoma (n = 133) and found cytoplasmic Skp2 expression was associated with overall (P = 0.025) and disease-specific five-year survival (P = 0.018) in primary melanoma patients (Figure 4C and D). The gene discussed is SKP2; the disease is melanoma.