FN1 and neoplasm: Indeed, anti-EDB antibodies localise to the subendothelial extracellular matrix around tumour blood vessels (Borsi et al, 2002; Niesner et al, 2002), and antibody-delivered PSs mediate the disruption of adjacent tumour vasculature by acting on proximal endothelial cells through diffusible reactive oxygen species (Josefsen and Boyle, 2008) or through local generation of heat (Chen et al, 1996; Yu et al, 2010).