It is reported that although the excision repair of cisplatin-induced intrastrand crosslinks in PC3 cells was attenuated to the same extent by XPA and ERCC1 knockdown, downregulation of ERCC1, but not XPA, sensitized PC3 prostate cancer cells to cisplatin [42], indicating the role of ERCC1 in the repair of interstrand crosslinks may be more important in cisplatin resistance. The gene discussed is ERCC1; the disease is prostate carcinoma.