A point mutation in the "halothane gene" or ryanodine receptor 1 (RYR1), the skeletal muscle sarcoplasmic reticulum Ca2+ release channel, has been identified in the pig [62] and has been associated with porcine stress syndrome (PSS), a sometimes fatal condition of malignant hyperthermia that is triggered by stress and is a major contributor to the development of PSE pork [60]. This evidence concerns the gene RYR1 and peeling skin syndrome.