In this study, we found that the mRNA and protein expression of SCGB3A2 (UGRP1) was dramatically down-regulated in both CRSsNP and CRSwNP, and SCGB3A2 (UGRP1) was mainly produced by epithelial cells in sinonasal mucosa, which is similar to the expression pattern of SCGB1A1 (CC10) [5-7]. The gene discussed is SCGB3A2; the disease is chronic rhinosinusitis with nasal polyps.