A significant negative correlation was found between SCGB3A2 (UGRP1) staining intensity and pre-operative CT scores (r = -0.54 and r = -0.45 in CRSsNP and CRSwNP group, respectively; P < 0.05 for both), but not pre-operative symptom scores. Here, SCGB3A2 is linked to chronic rhinosinusitis without nasal polyps.