The purposes of the present study were: (1) to examine the regulation of SCGBs mRNA expression other than SCGB1A1 (CC10) in human normal nasal mucosa by inflammatory cytokines; (2) to compare the expression levels of SCGBs in normal controls and CRSwNP and CRSsNP patients; and (3) to further study the SCGB3A2 (UGRP1) protein expression and its significance in CRS. The gene discussed is SCGB1A1; the disease is chronic rhinosinusitis with nasal polyps.