Choi et al found that SCGB1D4 (IIS) can modulate lymphoblast cell migration [3]; therefore, the enhanced expression of SCGB1D4 (IIS) in both CRSsNP and CRSwNP may contribute to the persistent immune responses in CRS. The gene discussed is SCGB1D4; the disease is chronic rhinosinusitis without nasal polyps.