Choi et al found that SCGB1D4 (IIS) can modulate lymphoblast cell migration [3]; therefore, the enhanced expression of SCGB1D4 (IIS) in both CRSsNP and CRSwNP may contribute to the persistent immune responses in CRS. This evidence concerns the gene SCGB1D4 and chronic rhinosinusitis with nasal polyps.