The unique increase of SCGB1C1 (RYD5) and decrease of SCGB3A1 (UGRP2) in CRSwNP, but not in CRSsNP, suggest that these two SCGBs may be more particularly involved in the polyp formation. The gene discussed is SCGB1C1; the disease is chronic rhinosinusitis with nasal polyps.