The IL8 781 C/C genotype was associated with younger age at RA diagnosis compared to both the IL8 781 C/T and T/T genotype (mean age (SD): IL8 781 T/T 52.2 (14) years, T/C 50.0 (14) years and C/C 44.2 (13) years, respectively, p < 0.01, after Bonferroni correction; Table 3). The gene discussed is CXCL8; the disease is rheumatoid arthritis.