In order to evaluate the EGFR and COX-2 expression and their impact on prognosis of NSCLC patients receiving post-operative adjuvant therapy, the paraffin embedded tumor samples from 50 NSCLC were analyzed immunohistochemically for EGFR and COX-2 expression and their prognostic values were explored. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.