An exploratory analysis of the effects of MTR, MTHFR, and the MTHFR by MTR interaction on hearing impairment with no adjustments conducted using the GENMOD procedure showed that the main effects of MTR and MTHFR and the interaction effect were significant (p = 0.0318, 0.0022, and 0.0076, respectively). The gene discussed is MTR; the disease is Hearing impairment.