By using a tissue explant culture model in examining the isolated skeletal muscle biopsies, MG132 treatment was further demonstrated to be successful in restoring the expression of the protein component of dystrophin-glycoprotein complex comprising dystrophin, β-dystroglycan, and α-sarcoglycan at the sarcolemma of muscles from patients with Duchenne muscular dystrophy (DMD) and Becker muscle dystrophy (BMD) [46]. The gene discussed is DMD; the disease is Duchenne muscular dystrophy.