TP53 and cancer: However, when analysing SCC and AC separately, a statistically significant relationship between TP53 mutation and 3q amplification was detected in AC samples, with amplification of 3q being significantly more common in TP53 mutant cancers (1/8 and 4/10 samples with 3q amplification in TP53 wild-type (wt) and mutant AC groups respectively, p = 0.027).