Much of the published data comparing gene expression profiles from primary CRC vs. CLM have reported the differences in up- or down-regulated genes.[35], [36], [37], [38], [39], [40], [41], [42], [43], [44] To the best of our knowledge, our data are the first to identify the expression of LEF1 as a predictor of overall survival, and an indicator of CLM. This evidence concerns the gene LEF1 and colorectal carcinoma.