In a gene-expression profiling study, Agrawal et al identified SPP1 as a lead marker correlating with CRC progression, and strongly expressed in CLM.[27], [28], [29] Most recently, Rohde et al observed that overexpression of SPP1 is indicative of poor survival in CRC and is significantly correlated with CLM.[30] In addition, overexpression of SPP1 correlates with increased immunohistochemical staining of β-catenin and, in an in vivo model, with Wnt activating mutations. Here, SPP1 is linked to colorectal carcinoma.