CXCL8 and bacterial infectious disease: The immunological consequences of CXCL8 increase at sites of chitin-skin interactions, however, could be two-faced: On the one hand, increased CXCL8 levels could feed the chemotactic gradient from skin-blood-bone marrow, thereby lowering the threshold for neutrophil recruitment upon later bacterial infections; on the other hand, chronic chitin stimulation may pave the way for the establishment and maintenance of auto-inflammatory skin inflammation.