Secondly, based on the seed sequence homology and the potential for regulating common targets such as Pu.1, BACH1, CEBPβ, HIVEP2, BCL2L13 and PDCD6, we have previously shown that miR-M4 is a functional ortholog of gga-miR-155 [19], a miRNA known to be directly associated with several cancers [23], [36] and molecular mechanisms of cancer pathogenesis [25], [26]. Here, SPI1 is linked to cancer.