FGF23 and colorectal cancer: Prior work has demonstrated that higher circulating FGF-23 is significantly associated with increased risk for cardiovascular disease, which shares many common risk factors with colorectal cancer, though the mechanism of action is currently unknown.[1] A direct relationship between FGF-23 and body weight has been reported;[17] however, in the present study no relationship between body mass index and FGF-23 was observed (data not shown).