To assess the signaling events associated with malignant mesothelioma cells, we determined the phosphorylation status of VEGFR-2, PKC-β2, and AKT in the presence of KRN633 and/or enzastaurin in normal mesothelial Met5A cell and H2461 cells [Figure 3b]. This evidence concerns the gene AKT1 and malignant mesothelioma.