Figure 2b shows the mean ± SD of duplicate determinations of the cytotoxicity assay. HUVEC response to VEGF was included as a positive control, and the cell viability was determined by alamar blue dye assay. There was no discernable effect on the survival of Met5A mesothelial cells when treated singly or with a combination of enzastaurin and KRN633. However, the cell viability in the various mesothelioma cell lines when treated with enzastaurin and/or KRN633 was significantly lower compared to the controls [Figure 2b]. Here, VEGFA is linked to mesothelioma.