There is no known curative modality for advanced MPM and long-term survival rate is low even with aggressive multimodality therapy.[1–2] VEGF is a critical angiogenic factor that plays a very important role in tumor growth and metastasis.[3] VEGFR, when ligated with its natural ligand VEGF, initiates a cascade of signaling events that ultimately result in tumor angiogenesis and neovascularization. This evidence concerns the gene KDR and neoplasm.