GPT and tuberculosis: Adult studies have shown that superboosting PI's may result in excess toxicity[10] and the Center for Disease Control and Prevention (CDC) cautions against TB co-treatment with super-boosted PI's.[25] In our cohort, there were no significant differences in the proportions of children with grade 3/4 ALT elevations in the TB co-treatment groups whilst receiving TB treatment compared to children on LPV/r alone.