PPARG and atherosclerosis: The question whether the beneficial effects of PPARγ was mediated by the altered systemic lipid homeostasis or by the altered phenotype of cells involved in the lesions, was investigated by Collins et al. They demonstrated that the anti-atherogenic effects of PPARγ and its beneficial effects on insulin sensitivity were uncoupled, suggesting that PPARγ ameliorated atherosclerosis by affecting cells locally [112].