Although the most impressive immunofluorescent evidence for increased pAKT signalling occurred in the hair-bearing skin of the outer lip, overall there is evidence of altered proliferation (increased EdU and Ki-67 staining) with cyclin D1 expression in the squamous epithelium of the wet oral mucosa, which is the cell type giving rise to the hyperplasia–papilloma–dysplasia–carcinoma sequence in this model. Here, CCND1 is linked to hyperplasia.