KRAS and oral cavity squamous cell carcinoma: Following analysis of micro-RNA expression patterns in human oral squamous cell carcinomas (OSCC), Shin et al6 concluded that miR-181a functions as an OSCC suppressor by targeting the K-RAS oncogene, suppressing expression of mutant K-RAS in OSCC cell lines and inhibiting their growth in culture, indicating the importance of mutated K-RAS as a driver mutation for OSCC growth.