BDNF and neoplasm: In RK3E cells, expression of TRKBD751N did not lead to tumor formation, even with high cell numbers and in the presence of BDNF, whereas RK3E TRKBT695I+BDNF-expressing cells formed tumors with a significant longer latency compared to RK3E TRKBwt+BDNF-expressing cells (Figure S2G).