LEP and Huntington disease: As part of an ongoing study on metabolic abnormalities in HD, we have been investigating a group of premanifest HD individuals over time using a number of different parameters.  In this paper we report on the change in body composition in such individuals and surprising show that premanifest individuals have significantly lower bone density compared to controls, that does not have an obvious explanation as they have normal levels of testosterone, cortisol, leptin and Vitamin D compared to age and sex matched controls.