To evaluate how STAT1 and STAT2 deficiency impacts the control of DENV infection, wild type, STAT1−/−, STAT2−/−, STAT1−/−/2−/−, and STAT1−/−/AR−/− mice were infected intravenously with 1010 GE of S221, and viral RNA levels in various tissues were measured via qRT-PCR at 6, 12, 18, 24, and 72 hours after infection. The gene discussed is STAT2; the disease is infection.