Of the 84 genes in the array, 31 (36.9%), 16 (19.0%), 22 (26.2%), and 7 (8.3%) genes, respectively, were induced 3-fold over naïve in wild type, STAT1−/−, STAT2−/−, and STAT1−/−/2−/− mice at 12 hours post-infection (Figure 4A), and the number of genes upregulated was similar at 24 hours post-infection for each mouse strain. The gene discussed is STAT1; the disease is infection.