STAT1 and infection: Following intravenous infection with 1010 GE of S221, 100% of STAT1−/−/AR−/− mice developed early lethal disease, whereas none of the STAT1−/−/GR−/− mice succumbed to infection (Figure 1C), demonstrating that the survival phenotype of STAT1−/−/AR−/− mice recapitulates that of STAT1−/−/2−/− mice.