CD209 and infection: Similarly, how DC-SIGN enhances viral uptake for infection (referred to as ‚cis-infection') or internalization into and storage in non-lysosomal compartments for subsequent transfer to conjugating T cells (referred to as ’trans-infection') is mechanistically not well understood, however, co-segregation or concentration of virions or their respective low level expressed uptake receptors has been proposed to contribute [1], [25].