This interaction, especially for viruses, does not promote sorting into degradative compartments, but rather, DC-SIGN mediated enhancement of DC cis-infection or trans-infection of T cells have been described, and these involve enhanced access to the DC cytoplasm (as for MV [9], [10], or surface trapping of virions (as for HIV and CMV [44], [45], [46]) whereby they are concentrated and stored in invaginated compartments with plasma membrane continuity for subsequent transfer to conjugating target cells. Here, CD209 is linked to infection.