In this regard, several studies have shown that blocking global cellular mRNA synthesis in human cancer cell lines by the Cdk inhibitors Roscovitine (Seliciclib, CYC202), Flavopiridol, DRB, and H7 induces a strong stress response resulting in nuclear accumulation of p53, induction of certain p53 target genes, and apoptosis [12-14]. This evidence concerns the gene TP53 and cancer.