This data set contained the mRNA expression profiles of healthy donors and multiple myeloma (MM) patients belonging to four categories - no cytogenetic abnormality, cytogenetic abnormality t(4;14) (with or without RB deletion), cytogenetic abnormality t(11;14) (with or without RB deletion), and RB deletion as a unique cytogenetic abnormality. Here, RB1 is linked to plasma cell myeloma.