The genes with loci showing relative hypermethylation in melanomas compared with nevi were KCNK4, GSTM2, TRIP6 (2 CpG sites), FRZB, COL1A2, and NPR2. The genes with relative hypomethylated loci in melanoma were CARD15/NOD2, KLK10, MPO, EVI2A, EMR3 (two sites), HLA-DPA1, PTHR1, IL2, TNFSF8, LAT, PSCA, IFNG, PTHLH, RUNX3 (three CpG sites), ITK, and CD2. ITK had a second CpG locus that was significantly different between melanomas and nevi but the β-value difference was <0.2. This evidence concerns the gene NOD2 and melanoma.