RUNX3 and melanoma: RUNX3 was previously reported to be hypermethylated in 23% of melanoma cell lines (Furuta et al., 2004) but only infrequently in 4% of primary melanomas (Kitago et al., 2009), but nevi were not examined in this study, making it unclear whether RUNX3 methylation levels were relatively increased or decreased with the acquisition of malignancy.