Among the CpG loci exhibiting hypermethylation in melanomas, FRZB_P406_F and COL1A2_E299_F were relatively unmethylated in nevi, having mean β-values near 0.1, but showed considerably higher methylation in many melanomas, with mean β-values between 0.6 and 0.7. The gene discussed is COL1A2; the disease is melanoma.