Eleven SNPs were significantly associated with prostate cancer risk, at a threshold of p<0.01 (ptrend<0.01 or p2df<0.01) (rs520820 in GADD45A; rs546950 and rs4955720 in PRKCI; rs706711, rs13156223 and rs831123 in PIK3R1; rs6797860 inTP63; rs11763144 in PRKAG2; rs388372 in RPS6KA2; rs13337626 in TSC2; rs3783501 in GADD45B). The gene discussed is PIK3R1; the disease is Familial prostate cancer.