TP is known to be a platelet-derived endothelial cell growth factor which has potent angiogenic activity.[12] This substance is expressed at higher levels in a wide variety of solid tumors compared to normal tissues.[13] Increased TP expression and activity was found to be associated with poor prognosis in various solid tumor tissues.[14] Several different angiogenic factors produced by tumor cells and host cells may regulate angiogenesis during different steps of esophageal carcinogenesis. Here, TYMP is linked to neoplasm.