To that end, Apolipoprotein (apo) E-deficient mice (6 weeks) were fed an atherogenic Western type diet (high fat, high cholesterol) enriched with i) 1% of a combination of EVO and seal oil (EVO/n-3), ii) 1% corn oil (CORN) or iii) no supplement (WD) for 12 weeks to study the impact on plasma lipids and the development of atherosclerosis. This evidence concerns the gene APOE and atherosclerosis.