ERBB2 and neoplasm: In contrast, a comparison between Fra-1 expression and clinico-pathological variables in IDC (Table 4) revealed an association between Fra-1 positivity and histological grade 2 or 3 tumours (P = 0.001), lack of ER expression (P = 0.015) and the presence of HER-2 overexpression (P < 0.004).