MAPT and frontotemporal dementia: FTD with tau-negative, ubiquitin-positive inclusions: This is the commonest pathological finding in FTD[70, 72, 73] and includes these with progranulin gene mutations.[74] The ubiquitinated protein has been identified as the transactive response DNA-binding protein with Mr 43 (TDP-43) which is also found in MND,[75, 76] strengthening the association between FTD and MND.