The role of p53 gene status [2], the presence of deletions in the INK4a/INK4b locus coding for the tumor suppressors and cell cycle regulators p16, p15 and p14ARF [3], the MGMT (O6-methylguanine DNA methyltransferase) levels [4] and the levels of expression for several players and regulators of apoptosis [5] were all studied to predict the response of the tumor to specific drugs. This evidence concerns the gene MGMT and neoplasm.